Endocrine Abstracts

The present study aimed to explore the relationship of sarcopenia, with or without the presence of obesity, with the risk of developing type 2 diabetes. We conducted a cross-sectional analysis of 2981 subjects in the Korean Genome and Epidemiology Study. The diabetes status of each subject was determined by using a 75 g oral glucose tolerance test, and body composition was estimated via dual-energy X-ray absorptiometry. The skeletal muscle mass index (SMI, %) was obtained by c...

Background: Growing evidence suggests a link between sugar-sweetened beverages (SSBs) and metabolic disorders. We investigated the effect of SSBs that are commonly consumed by adolescents on glucose metabolism and fatty liver.Methods: We treated 7-week old male C57BL/6 mice with water (control) or either of SSBs: carbonated soda (Coca-Cola®), sweetened milk coffee (Maxwell®), or chocolate-added cocoa (Choco-Latte&#174...

Insulin resistance (IR) may be defined as the physiological condition, in which insulin signaling is somehow deranged somewhat irreversibly such that insulin is of little use to cells or tissues. Specific roles of insulin are quite different in the muscle tissue, adipose tissue, and liver. Accordingly, detailed aspects of IR would be very tissue-specific. Meanwhile, IR may develop first in the muscle tissue with a relatively low cell turnover and then progress, in sequence, to...

Nonylphenol (NP), a member of alkylphenol family, has been widely used in both industry and household. NP is classified as an endocrine-disrupting chemical and is known to act as an agonist of the GPER (GPR30). The aim of this study was to address the two-generational effects of para-nonylphenol (NP) on the body weights, reproductive organ weights and histopathologies of ICR mice. We also test the potential reproductive toxicity of octylglucuronide (OG), a substitute candidate...

Background and aims: To evaluate the efficacy and safety of the newly developed dipeptidyl peptidase-4 (DPP-4) inhibitor evogliptin in drug-naïve patients with inadequately controlled type 2 diabetes.Materials and methods: In randomized, double-blind, placebo-controlled, parallel-group, multicenter, phase III study, 160 patients with type 2 diabetes were randomized to evogliptin 5 mg or placebo for 24 weeks. The primary efficacy outcome measure was ...

Maternal smoking during pregnancy is known to be related to adverse pregnancy results associated with trophoblast proliferation and cell cycle progression. Moreover, many previous studies have shown that cigarette smoke is correlated with human chorionic gonadotropin beta (hCG-β) subunit produced from syncytiotrophoblasts during pregnancy. Thus, we further investigated whether cigarette smoke extract (CSE) affects the cell proliferation, migration and endocrine hormone ac...

Background: Insulin-like growth factor-1 (IGF-1) is known to be closely related to the growth of thyroid cells and thyroid diseases. However, the association between IGF-1, thyroid nodule, and thyroid cancer has not been clearly established yet. Therefore, this study investigated the association between IGF-1 and thyroid nodule size.Methods: A total of 346 patients with thyroid nodules confirmed by ultrasonography were included. For all participants, the...

Background: UPEA for LRR in PTC was introduced in 1993 (JCEM 96:2717, 2011). It is not appreciated that such non-invasive ablations can often be repeated over decades (Surgery 154:1448, 2013). Skin metastases (SM) from thyroid carcinoma are typically associated with disseminated disease; average survival after SM diagnosis is 19 months (JAAD 36:531, 1997). Our case provides insights into managing LRR and SM in LRPTC.Clinical case: In 2004, an open biopsy...

Currently, no effective medical therapy exists for inoperable phaeochromocytomas (PCCs). Thus, we investigated the antitumor potential of the dual PI3K/mTOR inhibitor NVP-BEZ235 against PCC in vivo. We employed a spontaneous model of endogenous aggressive PCCs (MENX rats), which closely recapitulate the human tumours. Administration of NVP-BEZ235 to MENX rats for 14 days inhibited proliferation (assessed by Ki67, NuSAP staining), vascularity (CD31, VEGFA), and induced...

Introduction: Type 2 deiodinase (D2) catalyses intracellular T3 production in several human tissues including pituitary gland, hence occupying an important role in the feedback regulation of TSH secretion. Although several previous researches have shown that Thr92Ala D2 polymorphism with decreased D2 enzymatic activity influences the levothyroxine dose requirement and the set point of the hypothalamus–pituitary–thyroid axis for postoperative TSH suppressiv...